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Erastin blocks cystine absorption by suppressing system Xc , leading to intracellular cysteine depletion, which in turn causes membrane damage and subsequent cell death ( 2.4 GPX4-independent regulatory pathway Although GPX4 acts as a central suppressor of ferroptosis, three other ways to inhibit ferroptosis have been found, irrespective of GPX4

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Another study showed that every 1 mol of bilirubin scavenges 2 mol of oxygen free radicals, which in turn prevents excessive ROS from causing damage to the body (60)