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Neurological symptoms often develop gradually and may include: Paraesthesia : tingling or 'pins and needles' sensations, typically starting in the feet and hands Numbness : reduced sensation in the extremities, which may affect balance and coordination Burning pain : particularly in the feet, often worse at night Weakness : muscle weakness and difficulty walking Balance problems : unsteady gait and increased fall risk due to proprioceptive impairment Cognitive changes : memory problems, confusion, difficulty concentrating, and mood disturbances Haematological signs may accompany neurological symptoms and include fatigue, weakness, pallor, and shortness of breath due to megaloblastic anaemia

Gene 534 , 3339 (2014)

3 DMF Miscibility with Common Organic Solvents DMF is miscible with the vast majority of common organic solvents, owing to its combination of polar and non-polar structural features (the polar amide group plus the relatively non-polar methyl groups)

Cryo-EM map-based model validation using the false discovery rate approach