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This result indicates a dysregulated apoptotic balance rather than a direct stimulation of apoptosis, presumably reflecting altered cell turnover, compensatory responses, or temporal implications related to the prepubertal collection window

Microglia seem to play an important and dynamic role in BBB integrity in response to different insults

Stinging or Burning Sensation : Some users may experience a transient stinging or burning sensation upon application, which typically diminishes as the skin builds tolerance