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Otherwise, without therapy, reflecting a general stasis (i.e., large volume trapped in the CNS and portal and caval vein tributaries (i.e., seen with inferior caval vein venography) may perpetuate the brain and heart ischemia as well), thrombosis rapidly appears (i.e., 15 min)

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SAM levels were decreased, but S-adenosylhomocysteine (AdoHcy, SAH) levels were elevated considerably, with global DNA hypomethylation observed in both heterozygotes and homozygotes 38

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