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Oral semaglutide is indicated for use as an add-on combination therapy (with other glucose-lowering agents, including insulin) or as a monotherapy (in patients who are intolerant to metformin) for type 2 diabetes when diet and exercise do not provide adequate glycemic control

Factors affecting how fast semaglutide works for weight loss If you're taking semaglutide for weight loss, you may notice a reduction in appetite after a couple of weeks, but significant weight loss may take a bit longer

In studies, semaglutide medications were paired with structured lifestyle guidance, like Lowering the calorie intake: Often, people were guided to eat about 500 fewer calories per day than their maintenance needs to support steady weight loss

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