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Solubility is intrinsically a mesoscale phenomenon, making full first-principles simulation too costly to contemplate for routine usage, and depends on phenomena like crystal polymorphism and ionization state in complex and nonlinear ways, complicating attempts to build simple multilinear models

As shown in supplementary Fig 5a, b, serum and hepatic cholesterol levels were significantly increased after 12 h feeding

This would be adaptive because experience would not trigger immediate consolidation of all incoming information, and thus avoid simultaneous and complex regulation of different cascades of information storage (Redondo and Morris, 2011)