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doi: 10.1056/NEJMoa1107494 [PubMed] 24453083 Thakur KT, Probasco JC, Hocker SE, Roehl K, Henry B, Kossoff EH, Kaplan PW, Geocadin RG, Hartman AL, Venkatesan A, Cervenka MC

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Last updated: May 27, 2026 For patients taking Ozempic for weight management, discontinuation typically results in significant, rapid weight regain a phenomenon increasingly referred to clinically as the Ozempic rebound effect. Once the medication is stopped, all of its weight-relevant mechanisms reverse simultaneously: hypothalamic appetite suppression lifts, gastric emptying accelerates, and improvements in insulin sensitivity begin to wane