Although superoxide anion and hydrogen peroxide are not particularly reactive they may synergize with specific factors, eg iron, generating potent free radicals such as hydroxyl radical, which may cause direct injury through alteration of vital cellular macromolecules (DNA, protein or lipids)
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Both compounds are frequently discussed in musculoskeletal regenerative protocols due to their overlapping repair applications
doi:10.1073/pnas.0707258104
