Presented by Klara Rachel Klein, MD, PhD (University of North Carolina School of Medicine, Chapel Hill), at the American Diabetes Association (ADA) 2026 Scientific Sessions in New Orleans, the randomized, double-blind, 27-site trial compared HDV-LIS (n=112) with standard insulin lispro (n=114) in 226 adults with T1D, all on insulin degludec and a Dexcom G7 CGM
For researchers concerned about cardiovascular risk, practical strategies to minimize TMAO production include supporting a healthy gut microbiome through prebiotic and probiotic use, monitoring TMAO levels if testing is available, and keeping total levocarnitine exposure within studied safety ranges
Typical weekly range: 2.515 mg once weekly (gradual 4week titration steps)
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