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Adding complextity to BBB-microglia interaction, a study by Krasnow et al., revealed that murine brain microvascular endothelial cells exposed to IL-1 before co-cultured with microglia, amplifies inflammatory gene expression in microglia, as compared to IL-1 exposure of isolated microglia (Krasnow et al., 2017)

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Whilst observational studies suggest that regular oral coffee consumption may benefit liver health, coffee enemas carry significant risks including rectal perforation, electrolyte disturbances, and infection