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Both tirzepatide and semaglutide are well-characterised in type 2 diabetes research models, with extensive phase 3 trial data supporting their use in glycaemic endpoint studies

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Tirzepatide favors GIPR over GLP-1R activity and it is biased for cAMP over -arrestin recruitment at GLP-1R ( Following the initial reports of pharmacological and genetic deletion of GIPR, Killion et al

Until recently, glycemic control, blood pressure management, angiotensin converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARB) were the only available strategies to prevent diabetic kidney disease (DKD) progression