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doi:10.1515/BC.2008.111

[21] One meta-analysis of 12 randomized controlled trials, found that long-term (over six months) use of NAC reduced the risk of chronic obstructive pulmonary disease (which includes refractory asthma) becoming worse

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doi: 10.3389/fnagi.2025.1737001 Received 31 October 2025 Revised 13 December 2025 Accepted 17 December 2025 Published 10 February 2026 Volume 17 - 2025 Edited by Slawomir Jakiela, Warsaw University of Life Sciences, Poland Reviewed by Sajad Fakhri, Kermanshah University of Medical Sciences, Iran Emre Adigzel, Karamanolu Mehmetbey University, Trkiye Updates Copyright 2026 Guo and Chi