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The interactions of ligand receptor lead to adsorption and autophosphorylation in the GHR cytoplasmic domain, and the JAK2/GHR complex subsequently phosphorylates STAT molecules, modifies gene transcription, and significantly results in influences on the cell proliferation
doi: 10.1016/j.intimp.2024.112904 47 EmiliM.GuidiS.UguagliatiB.GiacominiA.BartesaghiR.StagniF
The current review emphasises the importance of the gut barrier in limiting the systemic entry of luminal contents and highlights how strategies to improve its integrity represent a useful approach in reducing the prevalence and burden of gut-associated and extraintestinal inflammatory diseases
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