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Our study demonstrated that Gln deprivation severely inhibited the tumor growth of HCC and PCa both in vivo and in vitro, and this occurs partially through reduced GSH levels, resulting in ROS accumulation

The safety profile, optimal dosing strategies, and long-term effects in humans have not been fully established

139 ) The association between NFS1 activity and cancer relates to temporary abrupt increases in oxygen tensions experienced by cancer cells that differently affect tumours according to their tissue and organ localisation

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