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To identify ACSL isoforms that contribute to ESA-induced ferroptosis, we individually knocked down expression of each of the five isoforms in BT-549 and MDA-MB-231 cells by RNAi (Supplementary Fig

Sampson et al

In a mouse model of SCA6, BDNF and TrkB were downregulated at the age-at-onset, and early activation of TrkB-AKT signalling improved symptoms 59 , supporting our previously unappreciated findings whereby early manipulation of TrkB signalling regulated pathways in which GSH metabolism is crucial to halt the degenerative process triggered in iSPNs lacking BDNF-TrkB signalling

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