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2.4 Correlation between GPX4 downregulation and OA severity Extensive clinical pathological analyses and rigorously controlled animal model studies collectively reveal a clear pattern: the protein expression level or biological activity of GPX4 typically shows a significant negative correlation with the severity of OA lesions

Horses with higher protein demands (e.g., growth, late gestation/lactation, intense work) or on lower-quality forage may require additional high-quality protein (such as alfalfa or soybean meal)

The work ahead will determine how far we can go in translating MGBA science into tangible clinical benefits, but the progress to date already suggests that the gut microbiome may become a cornerstone of precision medicine in neurology

10.1056/NEJMoa1012985 Floh L: Selenium, selenoproteins and vision