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Frataxin deficiency is associated with imbalances in iron-sulfur containing proteins, mitochondrial respiratory chain dysfunction and lower ATP production, and accumulation of iron in the mitochondria, which increases oxidative stress and oxidative damage to macromolecules of the respiratory chain (77)

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The FDA's 2023 Category 2 classification specifically restricts compounding pharmacies, while dietary supplements are regulated under DSHEA through a different pathway