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To determine whether this variant is likely to be causal, we considered all 42 variants within the 99% credible set of the association, and annotated by predicted functional consequence (Supplementary Table 9)

The effect of GLP-1 depends on blood glucose levels since it can only potentiate glucose-stimulated insulin secretion from islet beta cells in the hyperglycemic state rather than in the normal blood glucose state (95, 96)

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