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Damage of the brush borders could have been a result of toxin binding to the brush borders membrane 49
Further mechanistic studies revealed that LPS downregulates UFL1 expression, activates p53/SLC7A11 system, and modulates autophagy, thereby inducing ferroptosis ( 4.2.3 Bile acids Bile acids (BAs) metabolism disorders constitute a significant component of metabolic abnormalities in PCOS ( Notably, BAs -mediated activation of FXR has been reported to suppress lipid peroxidation and inhibit ferroptosis
54 Oral glutamine, for example, has been proposed to have a useful role in increasing host GSH concentrations in the gut, liver, lung, kidneys, heart, and muscle after exposure to radiation or chemotherapy without enhancing tumor growth
