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A newer peptide, Retatrutide , is a triple receptor agonist in development

However, strongest does not always mean best for every patient

NICE-approved weight management interventions include: Dietary and lifestyle modification first-line approach for all patients Orlistat licensed medication for obesity (BMI 30 or 28 with comorbidities) GLP-1 receptor agonists including semaglutide (Wegovy) per NICE TA875 and liraglutide (Saxenda) with restrictions per NICE TA664, for specific patient groups Bariatric surgery for severe obesity meeting strict criteria The NHS emphasises that sustainable weight loss requires behavioural change, nutritional education, and increased physical activity

However, if you would prefer to take a pill at home or are on a budget, then B12 pills may be a better choice