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10.3748/wjg.v22.i41.9127 [DOI] [PMC free article] [PubMed] [Google Scholar] Dobric I., Drvis P., Petrovic I., Shejbal D., Brcic L., Blagaic A

While this methylation reaction was historically considered a relatively minor metabolic pathway for nicotinamide clearance, research over the past decade has revealed that NNMT plays a surprisingly important and previously underappreciated role in cellular energy metabolism, NAD+ homeostasis, adipocyte biology, and whole-body metabolic regulation

For the foundational background article, see What Is Bacteriostatic Water