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Methionine is converted into SAM by a process that requires energy

In pernicious anemia, the immune system attacks a protein called intrinsic factor, which is required for B12 absorption and results in low B12 levels

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It is for these reasons that we positioned B cells at the interface between the CNS and the periphery in Figure 2, as these cells, or more likely, specifically modified subpopulations thereof, could act as a key bridge between acute/adaptive auto-immune attacks and a progressive cytodegenerative process within the CNS