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In some embodiments, the otoprotectant is a compound comprising a urea-thiophene-carboxamide moiety of Formula (III): wherein X is a heteroatom that includes N, O, or S

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Although the overall number (frequency) of Tregs may be unchanged in MS patients compared to controls, studies indicate that their inhibitory function is impaired, which correlates with diminished immune control in vivo ( Further studies have shown the absence of GSH in T cells does not interfere with TCR signaling but leads to a failure to reprogram cellular processes needed for robust clonal expansion and prevents the induction of aerobic glycolysis and the increase in cell size associated with T cell activation ( Overall, a decrease in GSH is seen across AD, PD, and MS

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