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(8) The increased IGF-1 may act on Leydig cells via the IGF-1 receptor, which is thought to be present on these cells, and has been posited to support their responsiveness to gonadotropins

Hidese S, Nogawa S, Saito K, Kunugi H

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The de novo designed peptides not only can induce efficient condensation of nucleic acids into compacted nanoparticles and protect them from enzymatic digestion but also can effectively overcome biological barriers and improve gene delivery efficiency through targeted delivery, enhanced cellular uptake, improved endolysosomal escape, and nuclear importation