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In STEP-1 (Wilding et al., NEJM 2021), 68 weeks of once-weekly 2.4 mg semaglutide plus lifestyle intervention produced a mean body-weight reduction of about 15%, versus about 2.4% with placebo a large, clinically meaningful, well-replicated effect

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GLP-2 and effects on bone metabolism In osteoporotic (SAMP6) mice, six-week treatment with GLP-2 was shown to reduce bone loss and improve bone microstructure

Current evidence supports the long-term safety of semaglutide, with clinical trial data extending to 2 years and real-world pharmacovigilance data now exceeding 5 years for the diabetes indication