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The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity

Understanding Liposomal Technology Liposomes are microscopic spherical vesicles composed of a phospholipid bilayer, similar to the structure of human cells

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Headache was reported as an adverse event during treatment with liraglutide, semaglutide, phentermine/topiramate, and naltrexone/bupropion, though it was not a severe adverse event