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Policy The data from a pharmacoepidemiologic study co-led by Cleveland Clinic researchers and published in Alzheimers & Dementia (2025;21[9]:e70639) offer compelling real-world evidence in support of ongoing randomized clinical trials investigating the therapeutic potential of these antidiabetic drug classes for neurodegenerative conditions

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The research demonstrates that effective doses typically fall within specific ranges [2]: The cagrilintide starting dose in most clinical protocols begins at 0.3 mg weekly, with gradual escalation over 8-12 weeks to minimize gastrointestinal side effects [3]