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As expected, the plaque-burdened AL-fed 3xTg females had significant neuroinflammation with higher levels of activated astrocytes (GFAP-positive) and microglia (IBA1-positive)

Topiramate is an antiepileptic drug that acts as a modulator of Na+ channels, GABA, and AMPA/kainate receptors, it is useful in the treatment of atypical psychoses of subjects with PWS and it is also known to affect food-seeking behavior [4]

Note any existing symptoms that might later be confused with peptide effects

These mild to moderate effects typically resolve as your body adjusts to the medication, and dosing schedules are designed to minimize discomfort