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It is far easier to start outright than to remove privileges because of weight gain

For a huge swath of the US population, about 40%, there now exists a therapeutic approach outside of surgery, known as GLP-1 agonists, that could improve the weight loss journey

Furthermore, because our study was conducted in normal aging rats, without diabetes or other pathological conditions such as Alzheimers disease, we aimed to use the lowest effective dose to minimize potential adverse effects while still achieving beneficial effects on the brain

Consistent with this finding, we observed less respiration in response to CI and III substrates in isolated gWAT mitochondria and primary adipocytes from mice lacking adipocyte Ndufs2 (Extended Data Fig