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autoimmune haemolytic anaemia, myasthenia gravis, idiopathic thrombocytopenic purpura, Sjogrens syndrome)[116]

documented the utility and current limitations of AOPs in regulatory risk assessment, noting that the framework supports hazard characterisation and integrated approaches to testing and assessment (IATA), but that quantitative response-response relationships remain underdeveloped (Bajard et al., 2022, DOI)