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While the amount of mature amyloid fibrils differs between tissues in HCCAA patients, it has been recently shown that the amount of deposits in the skin correlates with the symptomatic or asymptomatic status of patients, with higher deposition in skin observed in symptomatic individuals 22

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Although fibrous astrocytes are less frequently associated with classical tripartite synapses, they modulate axonal conduction and participate in axoglial interactions that share functional similarities with tripartite arrangements, thereby supporting neuronal communication and structural integrity