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The benefits often appear before weight loss occurs - cardiovascular risk drops within weeks, kidney function stabilizes, inflammation decreases, insulin sensitivity improves, and even osteoarthritis pain reduces as metabolic health improves

Additionally, targeted deletion of Ramp1 specifically in macrophages diminished pain-related behaviors and reduced lesion size and number, confirming the key role of CGRP/RAMP1-mediated nociceptor-to-macrophage communication as a novel avenue for immunotherapy and targeted molecular treatment in endometriosis, addressing both pain and lesion development

One was reported by Edgard Zunz and Jean La Barre, two physiologists at the University of Brussels