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On applying a very small quantity of the product on the skin, it gets absorbed by it

Note: these studies describe experimental endpoints and do not constitute medical claims

In the synovial fluid of individuals with OA, increased lactate facilitates lactylation of UDP-glucose dehydrogenase (UGDH) at lysine 6, disrupting its interaction with signal transducer and activator of transcription 1 (STAT1), suppressing its enzymatic activity and glycosaminoglycan synthesis, and altering its nuclear-cytoplasmic distribution, activating the MAPK signaling pathway and ultimately contributing to OA progression

Treatment adherence is improving: persistence improved from ~40% for those starting treatment in 2023 to 63% for those beginning in early 2024 (one-year continuation)