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Leslie Baumann in her fantastic Cosmetic Dermatology book writes that RP is topically ineffective

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No Fillers: We do not cut our Dihexa with mannitol or other bulking agents unless specifically requested for volumetric dosing

Recommendations for Those on T4-Only Medications T4-only medication (such as Synthroid, Levoxyl, Tirosint, Eltroxin, and generic levothyroxine) has a five- to nine-day half-life, which means that once you have become stable on the current dosage, it can take up to nine days for 50 percent of the dose to clear the body