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The intestinal epithelium is arranged in a single layer of columnar cells embedded with tight junction proteins [Claudin, Occludin, and Zonula occludens (ZO)] (36), while immunocytes, such as lymphocytes, plasma cells, and macrophages, are present in the lamina propria and participate in intestinal immune defense (37)

Accordingly, agents targeting the molecular participants in the Th2-high subtype (e.g., anti-IL-4, anti-IL-5, anti-IL-13, IgE blockers, and inhibitors of prostaglandin D2 (CRTH2) receptor) have recently been presented as potential drugs to treat asthma

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Effect of Oral Vitamin D3 on Dental Caries: An In-Vivo and In-Vitro Study