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(jofem.org) The best-case signal: modest weight loss in a shorter trial A frequently cited 12-week randomized trial result (as summarized in reviews) reported: ~2.6 kg average loss with AOD-9604 1 mg/day vs ~0.8 kg with placebo (PMC) This is the kind of result that can be statistically meaningful, clinically modest, and very sensitive to study design (diet, activity, baseline metabolic status, adherence)

A smaller subset (about 47% of trial participants) experience GI side effects severe enough to discontinue treatment

The needle should enter fully to the hub for proper subcutaneous placement

The FDA prescribing information lists diarrhea as an adverse reaction occurring in 30% of patients treated with the 2.4 mg injection compared with 16% on placebo in the weight-reduction trials