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[DOI] [PMC free article] [PubMed] [Google Scholar] 96.Leonard G.D., Fojo T., Bates S.E

6.3 Impact on myokine and adipokine signaling in the musclevascular network Beyond mere direct metabolic implications, this integrative framework modulates the signaling pathways of myokines and adipokines, thereby reinforcing the endocrine aspect of the interactions between muscle and vascular systems

SLNs have shown potential in the treatment of skin cancer by enhancing the delivery of chemotherapeutic agents directly to cancerous cells [118]

Emerging clinical data from retatrutide and survodutide suggest that this strategy may be viable, though long-term safety, durability, and comparative effectiveness remain under active investigation