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Under pathological conditions, they may initially exert neuroprotective effects, yet prolonged activation often results in metabolic disturbances and neurotoxic gliotransmission, highlighting their dual role in CNS pathology and their potential in therapy [293]

Ozempic (Semaglutide) Side Effects Drug class: GLP-1 receptor agonist Indications: Type 2 diabetes mellitus (and weight loss in some settings) Common Side Effects (Most frequent) Nausea Vomiting Diarrhea Constipation Abdominal pain or bloating Reduced appetite Usually dose-dependent and tend to improve with time

Appetite Suppression: Over-the-Counter (OTC) Appetite Suppressants For those seeking extra help with hunger management, these OTC options can be effective: Promotes mild hunger reduction, gut health, and regular bowel movements

Cost and consistency also matter, since skipping doses interrupts the pulse pattern the body relies on for steady growth hormone support