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The population in SELECT was different that STEP-1 and SUMOUNT 1, with 90.1% of patients on lipid-lowering therapy and a much lower baseline LDL-C of 78 mg/dL compared to 111 mg/dL and 110 mg/dL in STEP-1 and SURMOUNT 1 respectively [33, 35, 48]
The role of insulin-like growth factor 1 (IGF-1) in skeletal muscle growth and regeneration
Tirzepatide (Mounjaro, Zepbound) shows similar nausea incidence but adds dual GIP-receptor activation, which may increase gastrointestinal effects in some patients
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