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How much this role vs non-transmission-related functions of Agm mediate protection in age-related dementias is less clear, but a supporting role for Agm/Glu co-transmission is consistent with Agm protection against excitotoxicity in AD models (Zhu et al., 2003)
Limitations include limited large-scale human clinical evidence, challenges in extrapolating in-vitro concentrations to in-vivo contexts, stability sensitivities (light, heat, alkaline pH), and variability in supplier purity
Hanley, R
Eli Lilly and Company is currently researching a dual agonist called tirzepatide, which has outperformed semaglutide in phase 3 clinical trials
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