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| Parameter | Orforglipron (oral pill) | Retatrutide (injectable peptide) | | --- | --- | --- | | Molecular class | Non-peptide small molecule | Peptide (amino acid chain) | | Receptor profile | GLP-1 (single target) | GIP + GLP-1 + glucagon (triple) | | Administration | Oral, tablet | Subcutaneous injection | | Interval | Once daily | Once weekly | | Half-life | Short (daily dosing) | approx

GLP-1 and GIP are reported to bind their respective receptors on -cells in the pancreas in response to glucose (Figure 2)

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