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Description

Some cases are associated with systemic conditions , including Addison's disease, Peutz-Jeghers syndrome, McCune-Albright syndrome, and other rare syndromes (Box 10.1 in Neville)

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In addition, a meta-analysis and some placebo-controlled studies have suggested that melatonin supplementation may also have positive effects on autistic behavioural disorders

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Additional oral supplementation with polypodium leucotomos extract (PLE) at 480 mg twice daily can be helpful (anecdotal evidence, unpublished)

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