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This data is valuable because it captures effects in broader populations than clinical trials, including people with comorbidities, those taking multiple medications, and those using doses or schedules that differ from trial protocols

MR-PRESSO detected outliers in the overall associations with diabetes, LDL-cholesterol, HDL-cholesterol, apolipoprotein B and diastolic blood pressure, and sex-specific association with LDL-cholesterol, HDL-cholesterol, and apolipoprotein B (shown in Additional file 1: Table S5), where we used corrected estimates from MR-PRESSO