eli lilly retatrutide study Lilly's triple agonist hits 28.3% mean weight loss in TRIUMPH-1 phase 3, blowing past tirzepatide benchmarks & rewriting obesity math for payers, PBMs & the Novo Duopoly Tirzepatide shows 47% greater weight

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monitor blood glucose closely Symptoms of low blood sugar (shakiness, sweating, confusion) especially peri-workout or when fasted Injection site reactions (redness, bruising, discomfort) Theoretical growth-pathway concerns from strong IGF-1 receptor activation Risk of additive hypoglycemia when combined with insulin or other IGF-axis compounds avoid casual stacking Human safety is not established research-only and not FDA-approved IGF-1 DES (des(1-3)IGF-1) is a truncated 67-amino-acid analog of insulin-like growth factor-1 missing the N-terminal Gly-Pro-Glu tripeptide

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Brain: GLP-1 receptors are in the hypothalamus and pituitary - both central to the hormonal cascade governing GnRH, LH, and FSH production that regulates ovulation and the menstrual cycle