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, .161 , GLP-1 ,167,168 .136,169,170 .161,167 Small molecule GLP-1RAs Currently, most GLP-1RAs are based on proteins or peptides, meaning they are large molecules typically administered via injection.37 Small molecule GLP-1RAs are chemically synthesized, and compared to protein-based drugs, they generally have smaller molecular sizes.171 The development of small molecule GLP-1RAs aims to overcome some of the limitations of traditional protein or peptide-based GLP-1RAs, such as the need for injection
People with a personal or family history of medullary thyroid cancer or the MEN2 syndrome are generally advised against these drugs, which is a conversation for your doctor
For lipidated peptides the most valuable extra data point is aggregate content by size-exclusion chromatography RP-HPLC purity can read high while soluble aggregates are present, because aggregates often dissociate under the organic mobile phase
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