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In ME/CFS and Long COVID, researchers have identified a 'mitochondrial-peroxisomal vicious cycle.' As mitochondria attempt to generate adenosine triphosphate (ATP) for energy, damaged electron transport chains 'leak' electrons, creating highly reactive superoxide radicals

12 While our studies indicate BDHI-labeling of TG2 and ALDH1A1 is likely cysteine-directed, in the future it will be interesting to assess whether tighter-binding BDHIs may modify other amino acid targets

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