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Similar ramping neuronal activities were also found in the ventrolateral (VL) thalamus [339], and inactivation of the thalamus delayed self-timing [340], suggesting that the preparatory signals in the cerebellar nuclei might be sent through the thalamus to the cortex and regulate the timing of movement decisions

a one-week titration at 1 mg may improve early tolerability

It is important to highlight that the adoption of new and more appropriate terminology would require universal acceptance by clinicians, carers and patients who would have lived with the name PA for most of their lives

Patients who arent fully meeting their health goals with either therapy alone may find the combination worth discussing with a clinician