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Liraglutide also induction HO-1 expression by activating AMPK and promoting HIF-1 protein export from cytoplasm to nucleus, which significantly increases the expression of anti-apoptotic protein Bcl-2 and decreases the expression of pro-apoptotic Bax and Caspase-3 in HUVECs cells [134]

The satisfying reproducibility of the MPTP-induced PD symptoms, pathological changes, and mitochondrial dysfunction in primates makes it the most valuable and practical model for PD studies at present

The study also recommended that vegans and vegetarians take B12 supplements to make sure that their bodies get enough of this vitamin to support essential bodily functions

10.1146/annurev.nutr.012809.104810 279 TohT