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This study was approved by Western University of Health Sciences Institutional Review Board (IRB)

Santos LC, Santana LR, Niella RV, Machado WM, Silva JF, Snoeck P (2024) Modulatory effect of vitamin B6 on sex hormone receptors, thyroid, and kisspeptin/kiss1r system in the uterus of pseudopregnant bitches

Yet only 4 to 6% of participants discontinued the drug in these trials, mostly owing to these GI side effects (and 1-2% in the placebo group discontinued the study drug for the same reasons)