In this review, we are focusing on translational biomarkers that can be detected in biofluids since biofluids can be easily obtained in the clinic
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Image description: Infographic provides overdose information about the following substances: Opiates Unresponsive or unconscious, depressed or nonexistent breathing, snoring/gurgling sounds, cold/clammy skin, cyanotic skin discoloration Methamphetamines Agitation, chest pain, arrythmia, cardiac arrest, stroke, kidney damage, abdominal pain, coma Gabapentin Drowsiness, muscle weakness, sedation, drooping eyelids (Rarely fatal alone) Benzodiazepines Excessive sedation, amnesia, respiratory depression, coma (Rarely fatal alone) Isotonitazene Similar to other opiates, but 10x more potent than fentanyl-requires significantly more Narcan doses
Zinc-2-glycoprotein (ZAG) is a glycoprotein with a zinc-binding site that plays a pivotal role in lipid metabolism